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dc.contributor.authorKang, Ki Sung-
dc.contributor.authorKim, Hyun Young-
dc.contributor.authorYoo, Hye Hyun-
dc.contributor.authorPiao, Xiang Lan-
dc.contributor.authorHam, Jungyeob-
dc.contributor.authorYang, Hyun Ok-
dc.contributor.authorPark, Jeong Hill-
dc.date.accessioned2024-01-20T15:33:33Z-
dc.date.available2024-01-20T15:33:33Z-
dc.date.created2021-09-05-
dc.date.issued2012-01-01-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/129653-
dc.description.abstractThe effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, Delta(20(21))-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of Delta(20(21))-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress. (C) 2011 Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectRADICAL-SCAVENGING ACTIVITY-
dc.subjectHEAT-PROCESSED GINSENG-
dc.subjectDIABETIC-NEPHROPATHY-
dc.subjectRENAL DAMAGE-
dc.subjectGINSENOSIDES-
dc.subjectOXYGEN-
dc.subjectANTIOXIDANT-
dc.subjectREDUCTION-
dc.subjectRATS-
dc.subjectRB-1-
dc.titleProtective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2011.10.063-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.22, no.1, pp.634 - 637-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume22-
dc.citation.number1-
dc.citation.startPage634-
dc.citation.endPage637-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000298636700125-
dc.identifier.scopusid2-s2.0-84655161551-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusRADICAL-SCAVENGING ACTIVITY-
dc.subject.keywordPlusHEAT-PROCESSED GINSENG-
dc.subject.keywordPlusDIABETIC-NEPHROPATHY-
dc.subject.keywordPlusRENAL DAMAGE-
dc.subject.keywordPlusGINSENOSIDES-
dc.subject.keywordPlusOXYGEN-
dc.subject.keywordPlusANTIOXIDANT-
dc.subject.keywordPlusREDUCTION-
dc.subject.keywordPlusRATS-
dc.subject.keywordPlusRB-1-
dc.subject.keywordAuthorPanax ginseng-
dc.subject.keywordAuthorRenoprotective activity-
dc.subject.keywordAuthorGinsenoside-
dc.subject.keywordAuthorSapogenin-
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