DSpace at KIST: Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage

Protective effect of ginseng sapogenins against 2,2 '-azobis (1-aminopropane) dihydrochloride (AAPH)-induced LLC-PK1 cell damage

Authors: Kang, Ki Sung; Kim, Hyun Young; Yoo, Hye Hyun; Piao, Xiang Lan; Ham, Jungyeob; Yang, Hyun Ok; Park, Jeong Hill

Citation: Bioorganic & Medicinal Chemistry Letters, v.22, no.1, pp.634 - 637

Abstract: The effect of ginseng sapogenins, aglycone parts of ginsenosides, against oxidative damage by radical generator, 2,2'-azobis (2-amidinopropane) dihydrochloride (AAPH), in renal epithelial LLC-PK1 cells was investigated to identify the structural characteristics of sapogenins to have renoprotective effects. Of the tested sapogenins, Delta(20(21))-protopanaxatriol showed the strongest protective effect against the AAPH-induced LLC-PK1 cell damage. Based on the structure and stronger activity of Delta(20(21))-protopanaxatriol than the other sapogenins, the hydroxyl group in C-6 and double bond in C-20(21) position were important for renoprotective effect of sapogenin against oxidative stress. (C) 2011 Elsevier Ltd. All rights reserved.

Keywords: RADICAL-SCAVENGING ACTIVITY; HEAT-PROCESSED GINSENG; DIABETIC-NEPHROPATHY; RENAL DAMAGE; GINSENOSIDES; OXYGEN; ANTIOXIDANT; REDUCTION; RATS; RB-1; RADICAL-SCAVENGING ACTIVITY; HEAT-PROCESSED GINSENG; DIABETIC-NEPHROPATHY; RENAL DAMAGE; GINSENOSIDES; OXYGEN; ANTIOXIDANT; REDUCTION; RATS; RB-1; Panax ginseng; Renoprotective activity; Ginsenoside; Sapogenin

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