alpha- and gamma-Mangostin inhibit the proliferation of colon cancer cells via beta-catenin gene regulation in Wnt/cGMP signalling

Authors
Yoo, Ji-HyeKang, KyungsuJho, Eun HyeChin, Young-WonKim, JinwoongNho, Chu Won
Issue Date
2011-12-15
Publisher
ELSEVIER SCI LTD
Citation
FOOD CHEMISTRY, v.129, no.4, pp.1559 - 1566
Abstract
Aberrant activation of Wnt/beta-catenin signalling via genetic errors within beta-catenin or APC has a crucial role in carcinogenesis. Here, we studied two xanthones, alpha- and gamma-mangostin, as inhibitors of Wnt/beta-catenin signalling. The mangostins inhibited TCF/beta-catenin transcriptional activity. The mangostins also inhibited protein expression of beta-catenin in colon cancer cells, but the inhibition was independent of the phosphorylation and degradation of beta-catenin. Instead, the mangostins increased the levels of cGMP and cGMP-dependent kinase, indicating that the inhibition of beta-catenin resulted from beta-catenin gene regulation. Our results indicate that mangostins could be potential candidates for preventing colon cancer through a novel mechanism of inhibiting Wnt/beta-catenin signalling. (C) 2011 Elsevier Ltd. All rights reserved.
Keywords
COLORECTAL-CANCER; GARCINIA-MANGOSTANA; PROTEIN-KINASE; WNT PATHWAY; CYCLIC-GMP; DERIVATIVES; EXPRESSION; PREVENTION; XANTHONES; MUTATIONS; COLORECTAL-CANCER; GARCINIA-MANGOSTANA; PROTEIN-KINASE; WNT PATHWAY; CYCLIC-GMP; DERIVATIVES; EXPRESSION; PREVENTION; XANTHONES; MUTATIONS; Mangostins; beta-Catenin; Transcriptional regulation; cGMP; PKG
ISSN
0308-8146
URI
https://pubs.kist.re.kr/handle/201004/129713
DOI
10.1016/j.foodchem.2011.06.007
Appears in Collections:
KIST Article > 2011
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