Facile synthesis and biological evaluation of 3,3-diphenylpropanoyl piperazines as T-type calcium channel blockers

Authors
Choi, Yeon-heeBaek, Du JongSeo, Seon HeeLee, Jae KyunPae, Ae NimCho, Yong SeoMin, Sun-Joon
Issue Date
2011-01
Publisher
Pergamon Press Ltd.
Citation
Bioorganic & Medicinal Chemistry Letters, v.21, no.1, pp.215 - 219
Abstract
We have developed a facile synthesis of 3,3-diphenylpropanamides using Meldrum's acid derivatives as amide coupling components. The in vitro biological evaluation of the title compounds led to the identification of compound 1h, which has good inhibitory activity against T-type calcium channel (IC50 = 0.83 mu M). (C) 2010 Elsevier Ltd. All rights reserved.
Keywords
MELDRUMS ACIDS; DERIVATIVES; EFFICIENT; ANALOGS; MELDRUMS ACIDS; DERIVATIVES; EFFICIENT; ANALOGS; T-Type calcium channel blockers; Meldrum' s acid; 3,3-Diphenylpropanoyl piperazine; HTS assays
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/130797
DOI
10.1016/j.bmcl.2010.11.033
Appears in Collections:
KIST Article > 2011
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