DSpace at KISTKIST Article2010

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dc.contributor.authorOh, Chang Hyun-
dc.contributor.authorLiu, Lian Jin-
dc.contributor.authorHong, Joon Hee-
dc.date.accessioned2024-01-20T18:32:34Z-
dc.date.available2024-01-20T18:32:34Z-
dc.date.created2021-09-05-
dc.date.issued2010-10-
dc.identifier.issn1525-7770-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131072-
dc.description.abstractA novel 3',4'-dimethyl-5'-norcarbocyclic adenosine phosphonic acid was prepared using acyclic stereoselective route from 4-hydroxybutan-2-one (4). To improve the cellular permeability and enhance the anti-HIV activity of this phosphonic acid, a (bis)SATE phosphonodiester nucleoside prodrug (20) was prepared and its chemical stability was evaluated. The newly synthesized bis(SATE) analogue (20) and its parent nucleoside phosphonic acid (18) were assayed for anti-HIV activity using an in vitro assay system in a CEM cell line.-
dc.languageEnglish-
dc.publisherTAYLOR & FRANCIS INC-
dc.subjectHCMV ACTIVITY-
dc.subjectNUCLEOSIDES-
dc.subjectMETABOLISM-
dc.subjectDELIVERY-
dc.subjectAGENTS-
dc.titleDesign and Synthesis of Dually Branched 5'-Norcarbocyclic Adenosine Phosphonodiester Analogue as a New Anti-HIV Prodrug-
dc.typeArticle-
dc.identifier.doi10.1080/15257770.2010.509645-
dc.description.journalClass1-
dc.identifier.bibliographicCitationNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.29, no.10, pp.721 - 733-
dc.citation.titleNUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS-
dc.citation.volume29-
dc.citation.number10-
dc.citation.startPage721-
dc.citation.endPage733-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000282581000001-
dc.identifier.scopusid2-s2.0-77957979311-
dc.relation.journalWebOfScienceCategoryBiochemistry & Molecular Biology-
dc.relation.journalResearchAreaBiochemistry & Molecular Biology-
dc.type.docTypeArticle-
dc.subject.keywordPlusHCMV ACTIVITY-
dc.subject.keywordPlusNUCLEOSIDES-
dc.subject.keywordPlusMETABOLISM-
dc.subject.keywordPlusDELIVERY-
dc.subject.keywordPlusAGENTS-
dc.subject.keywordAuthorAnti-HIV agent-
dc.subject.keywordAuthorbis(SATE) derivative-
dc.subject.keywordAuthornucleoside adenine phosphonic acid-
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