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dc.contributor.authorLee, W.-
dc.contributor.authorKim, S.-N.-
dc.contributor.authorYoon, G.-
dc.date.accessioned2024-01-20T18:34:27Z-
dc.date.available2024-01-20T18:34:27Z-
dc.date.created2021-09-02-
dc.date.issued2010-09-
dc.identifier.issn0253-3073-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131158-
dc.description.abstractProtein tyrosine phosphatase 1B (PTP1B) is predicted to be therapeutic target in treatment of type 2 diabetes and obesity. Thus, in order to search for PTP1B inhibitors, we screened the inhibitory activity of PTP1B in the water extracts of 84 medicinal herbs. Among them, the extracts of Pini Folium, Magnoliae Cortex, Artemisiae asiaticae Herba, Schizonepetae Herba, Menthae Herba, Mume Fructus, Cimicifugae Rhizoma, and Amomi Cardamomi Fructus showed relatively significant (58-68%) inhibitory activity against PTP1B. Especially, the methylene chloride fraction of the methanol extract of Menthae Herba (81% inhibition at 30 μg/ml) showed more potent inhibitory activity against PTP1B than others.-
dc.languageKorean-
dc.subjectAmomi cardamomi fructus extract-
dc.subjectArtemisiae asiaticae herba extract-
dc.subjectCimicifugae rhizoma extract-
dc.subjectdichloromethane-
dc.subjectMagnoliae cortex extract-
dc.subjectMenthae herba extract-
dc.subjectMume fructus extract-
dc.subjectPini folium extract-
dc.subjectplant extract-
dc.subjectprotein tyrosine phosphatase 1B-
dc.subjectSchizonepetae herba extract-
dc.subjectunclassified drug-
dc.subjectAmomi cardamomi fructus-
dc.subjectArtemisiae asiaticae herba-
dc.subjectarticle-
dc.subjectCimicifugae rhizoma-
dc.subjectdrug activity-
dc.subjectdrug screening-
dc.subjectenzyme inhibition-
dc.subjectMagnoliae cortex-
dc.subjectmedicinal plant-
dc.subjectMenthae herba-
dc.subjectMume fructus-
dc.subjectPini folium-
dc.subjectSchizonepetae herba-
dc.titleScreening of medicinal herbs for inhibitory activity against protein tyrosine phosphatase 1B-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationKorean Journal of Pharmacognosy, v.41, no.3, pp.227 - 231-
dc.citation.titleKorean Journal of Pharmacognosy-
dc.citation.volume41-
dc.citation.number3-
dc.citation.startPage227-
dc.citation.endPage231-
dc.description.journalRegisteredClassscopus-
dc.description.journalRegisteredClasskci-
dc.identifier.kciidART001485202-
dc.identifier.scopusid2-s2.0-79952378318-
dc.type.docTypeArticle-
dc.subject.keywordPlusAmomi cardamomi fructus extract-
dc.subject.keywordPlusArtemisiae asiaticae herba extract-
dc.subject.keywordPlusCimicifugae rhizoma extract-
dc.subject.keywordPlusdichloromethane-
dc.subject.keywordPlusMagnoliae cortex extract-
dc.subject.keywordPlusMenthae herba extract-
dc.subject.keywordPlusMume fructus extract-
dc.subject.keywordPlusPini folium extract-
dc.subject.keywordPlusplant extract-
dc.subject.keywordPlusprotein tyrosine phosphatase 1B-
dc.subject.keywordPlusSchizonepetae herba extract-
dc.subject.keywordPlusunclassified drug-
dc.subject.keywordPlusAmomi cardamomi fructus-
dc.subject.keywordPlusArtemisiae asiaticae herba-
dc.subject.keywordPlusarticle-
dc.subject.keywordPlusCimicifugae rhizoma-
dc.subject.keywordPlusdrug activity-
dc.subject.keywordPlusdrug screening-
dc.subject.keywordPlusenzyme inhibition-
dc.subject.keywordPlusMagnoliae cortex-
dc.subject.keywordPlusmedicinal plant-
dc.subject.keywordPlusMenthae herba-
dc.subject.keywordPlusMume fructus-
dc.subject.keywordPlusPini folium-
dc.subject.keywordPlusSchizonepetae herba-
dc.subject.keywordAuthorMedicinal herb-
dc.subject.keywordAuthorMenthae herba-
dc.subject.keywordAuthorObesity-
dc.subject.keywordAuthorProtein tyrosine phosphatase 1B-
dc.subject.keywordAuthorType 2 diabetes-
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