Kinetic analysis of the MAPK and PI3K/Akt signaling pathways

Authors
Suresh, Babu C., VBabar, Sheikh Md. EnayetulSong, Eun JooOh, EulsikYoo, Young Sook
Issue Date
2008-05-31
Publisher
KOREAN SOC MOLECULAR & CELLULAR BIOLOGY
Citation
MOLECULES AND CELLS, v.25, no.3, pp.397 - 406
Abstract
Computational modeling of signal transduction is currently attracting much attention as it can promote the understanding of complex signal transduction mechanisms. Although several mathematical models have been used to examine signaling pathways, little attention has been given to crosstalk mechanisms. In this study, an attempt was made to develop a computational model for the pathways involving growth-factor-mediated mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3'-kinase/protein kinase B (PI3K/Akt). In addition, the dynamics of the protein activities were analyzed based on a set of kinetic data. The simulation approach integrates the information on several levels and predicts systems behavior. The in-silico analysis conducted revealed that the Raf and Akt pathways act independently.
Keywords
ACTIVATED PROTEIN-KINASE; EPIDERMAL-GROWTH-FACTOR; SYSTEMS BIOLOGY; PHOSPHATASE 2A; REGULATED KINASES; RAF; AKT; RECEPTOR; MECHANISM; 3-KINASE; ACTIVATED PROTEIN-KINASE; EPIDERMAL-GROWTH-FACTOR; SYSTEMS BIOLOGY; PHOSPHATASE 2A; REGULATED KINASES; RAF; AKT; RECEPTOR; MECHANISM; 3-KINASE; biochemical pathway; computational modeling; MAPK; PI3K/Akt; signal transduction; systems biology
ISSN
1016-8478
URI
https://pubs.kist.re.kr/handle/201004/133475
Appears in Collections:
KIST Article > 2008
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE