Indinavir increases glucose production in healthy HIV-negative men

Authors
Schwarz, JMLee, GAPark, SNoor, MALee, JWen, MLo, JCMulligan, KSchambelan, MGrunfeld, C
Issue Date
2004-09-03
Publisher
LIPPINCOTT WILLIAMS & WILKINS
Citation
AIDS, v.18, no.13, pp.1852 - 1854
Abstract
In the absence of HIV infection, changes in adipose tissue and lipid levels, HIV protease inhibitor therapy increases fasting glucose levels, suggestive of hepatic insulin resistance. After 4 weeks of indinavir treatment in nine HIV-negative healthy men, fasting glucose production and glycogenolysis were significantly increased. During the euglycemic hyperinsulinemic clamp, indinavir blunted the ability of insulin to suppress glucose production. Therefore, indinavir worsens hepatic insulin sensitivity, increasing endogenous glucose production.
Keywords
INSULIN; HUMANS; INSULIN; HUMANS; indinavir; glucose production; HIV
ISSN
0269-9370
URI
https://pubs.kist.re.kr/handle/201004/137239
DOI
10.1097/00002030-200409030-00017
Appears in Collections:
KIST Article > 2004
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