Antiinflammatory activity of hyperin from Acanthopanax chiisanensis roots
- Authors
- Lee, S; Jung, SH; Lee, YS; Yamada, M; Kim, BK; Ohuchi, K; Shin, KH
- Issue Date
- 2004-06
- Publisher
- PHARMACEUTICAL SOCIETY KOREA
- Citation
- ARCHIVES OF PHARMACAL RESEARCH, v.27, no.6, pp.628 - 632
- Abstract
- The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E-2 (PGE(2)) production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA). Hyperin was isolated as an active principle from the ethyl acetate fraction. It suppressed not only PGE2 production but also nitric oxide (NO) production in vitro in a concentration dependent manner, their IC50, being 24.3 and 32.9 muM, respectively. Hyperin also caused a significant inhibition of increase in acetic acid-induced vascular permeability in mice in vivo.
- Keywords
- INHIBITION; STIMULATION; MACROPHAGES; PROTEIN; INHIBITION; STIMULATION; MACROPHAGES; PROTEIN; Acanthopanax chiisanensis; Araliaceae; hyperin; anti-inflammatory activity
- ISSN
- 0253-6269
- URI
- https://pubs.kist.re.kr/handle/201004/137557
- DOI
- 10.1007/BF02980162
- Appears in Collections:
- KIST Article > 2004
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