Antiinflammatory activity of hyperin from Acanthopanax chiisanensis roots

Authors
Lee, SJung, SHLee, YSYamada, MKim, BKOhuchi, KShin, KH
Issue Date
2004-06
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.27, no.6, pp.628 - 632
Abstract
The chloroform and the ethyl acetate fractions from the roots of Acanthopanax chiisanensis exhibited a significant inhibition of prostaglandin E-2 (PGE(2)) production in rat peritoneal macrophages stimulated by the protein kinase C activator, 12-O-tetradecanoylphorbol 13-acetate (TPA). Hyperin was isolated as an active principle from the ethyl acetate fraction. It suppressed not only PGE2 production but also nitric oxide (NO) production in vitro in a concentration dependent manner, their IC50, being 24.3 and 32.9 muM, respectively. Hyperin also caused a significant inhibition of increase in acetic acid-induced vascular permeability in mice in vivo.
Keywords
INHIBITION; STIMULATION; MACROPHAGES; PROTEIN; INHIBITION; STIMULATION; MACROPHAGES; PROTEIN; Acanthopanax chiisanensis; Araliaceae; hyperin; anti-inflammatory activity
ISSN
0253-6269
URI
https://pubs.kist.re.kr/handle/201004/137557
DOI
10.1007/BF02980162
Appears in Collections:
KIST Article > 2004
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