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dc.contributor.authorYoo, H.-
dc.contributor.authorLee, J.Y.-
dc.contributor.authorPark, J.H.-
dc.contributor.authorChung, B.Y.-
dc.contributor.authorLee, Y.S.-
dc.date.accessioned2024-01-21T08:02:20Z-
dc.date.available2024-01-21T08:02:20Z-
dc.date.created2021-09-02-
dc.date.issued2003-12-
dc.identifier.issn0014-827X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/138068-
dc.description.abstractA series of styrylbenzofuran derivatives (8a-i) as styrylquinoline isosters were efficiently prepared by Wittig reaction and evaluated for inhibitory activity against HIV-1 integrase. In this series, compounds 8g, 8h and 8i containing a free catechol ring showed moderate inhibitory activities (IC50=∼40 μM) against HIV-1 integrase, while less than the corresponding styrylquinoline compound (I). ？ 2003 ？ditions scientifiques et m？dicales Elsevier SAS. All rights reserved.-
dc.languageEnglish-
dc.publisherElsevier Masson SAS-
dc.subject7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid-
dc.subject7 hydroxy 2 [2 (4 hydroxyphenyl)ethynyl] 6 benzofuran carboxylic acid-
dc.subject7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid-
dc.subjectbenzofuran derivative-
dc.subjectintegrase inhibitor-
dc.subjectmethyl 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subjectmethyl 7 hydroxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subjectmethyl 7 methoxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subjectmethyl 7 methoxy 2 [2 (3,4 dimethoxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subjectmethyl 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subjectmethyl 7 methoxy 2 [2 (4 methoxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subjectquinoline derivative-
dc.subjectunclassified drug-
dc.subjectarticle-
dc.subjectdrug activity-
dc.subjectdrug screening-
dc.subjectdrug structure-
dc.subjectdrug synthesis-
dc.subjectenzyme inhibition-
dc.subjectHuman immunodeficiency virus 1-
dc.subjectIC 50-
dc.subjectnonhuman-
dc.subjectWittig reaction-
dc.titleSynthesis of styrylbenzofuran derivatives as styrylquinoline analogues for HIV-1 integrase inhibitor-
dc.typeArticle-
dc.identifier.doi10.1016/j.farmac.2003.08.001-
dc.description.journalClass1-
dc.identifier.bibliographicCitationFarmaco, v.58, no.12, pp.1243 - 1250-
dc.citation.titleFarmaco-
dc.citation.volume58-
dc.citation.number12-
dc.citation.startPage1243-
dc.citation.endPage1250-
dc.description.journalRegisteredClassscopus-
dc.identifier.scopusid2-s2.0-0242468157-
dc.type.docTypeArticle-
dc.subject.keywordPlus7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid-
dc.subject.keywordPlus7 hydroxy 2 [2 (4 hydroxyphenyl)ethynyl] 6 benzofuran carboxylic acid-
dc.subject.keywordPlus7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylic acid-
dc.subject.keywordPlusbenzofuran derivative-
dc.subject.keywordPlusintegrase inhibitor-
dc.subject.keywordPlusmethyl 7 hydroxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subject.keywordPlusmethyl 7 hydroxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subject.keywordPlusmethyl 7 methoxy 2 [2 (3,4 dihydroxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subject.keywordPlusmethyl 7 methoxy 2 [2 (3,4 dimethoxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subject.keywordPlusmethyl 7 methoxy 2 [2 (4 hydroxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subject.keywordPlusmethyl 7 methoxy 2 [2 (4 methoxyphenyl)ethenyl] 6 benzofuran carboxylate-
dc.subject.keywordPlusquinoline derivative-
dc.subject.keywordPlusunclassified drug-
dc.subject.keywordPlusarticle-
dc.subject.keywordPlusdrug activity-
dc.subject.keywordPlusdrug screening-
dc.subject.keywordPlusdrug structure-
dc.subject.keywordPlusdrug synthesis-
dc.subject.keywordPlusenzyme inhibition-
dc.subject.keywordPlusHuman immunodeficiency virus 1-
dc.subject.keywordPlusIC 50-
dc.subject.keywordPlusnonhuman-
dc.subject.keywordPlusWittig reaction-
dc.subject.keywordAuthorAIDS-
dc.subject.keywordAuthorHIV-
dc.subject.keywordAuthorIntegrase inhibitor-
dc.subject.keywordAuthorStyrylbenzofuran-
dc.subject.keywordAuthorWittig reaction-
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