Component effects on the phase behavior of monoglyceride-water mixtures studied by FT-IR and X-ray diffraction

Abstract

The unit cell dimensions of the cubic monoglyceride (MO)-water phases were studied by x-ray diffraction (XRD) when pure water was replaced by Iopamiro (Iopamidol aqueous solution). The XRD results suggested that there were no significant differences when pure water was replaced by Iopamiro, only at 30 wt % composition, the lattice parameter of the cubic phase (space group Ia3d) became slightly smaller when lopamiro was used. The interactions among Iopamidol, Paclitaxel, PF-127 and MO were also studied by Fourier-transform infrared (FT-IR) spectroscopy. The FT-IR data indicated a somewhat disordered conformation of the MO acyl chain and structural rearrangements of the polar head-group region in the cubic MO-water phases when the several components were added to this system. All findings in this report revealed that three components studied here could be added to this cubic phases and did not induce significant changes in the phase behavior of cubic MO-water phases.