DSpace at KIST: Synthesis and biological evaluation of thymine nucleosides fused with 3 ',4 '-tetrahydrofuran ring

Browse

My Repository

DSpace at KISTKIST Article 2003

Synthesis and biological evaluation of thymine nucleosides fused with 3 ',4 '-tetrahydrofuran ring

Authors: Kim, MJ; Kim, HO; Kim, HD; Kim, JH; Jeong, LS; Chun, MW

Issue Date: 2003-10-20

Publisher: PERGAMON-ELSEVIER SCIENCE LTD

Citation: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.13, no.20, pp.3499 - 3501

Abstract: The pyrimidine nucleosides fused with 3',4'-tetrahydrofuran ring were successfully synthesized, starting from 1,2;5,6-di-O-isopropylidene-D-glucose and assayed for antiviral activities against HIV-1, HIV-2, EMCV, Cox. B3 and VSV. Thymine analogue (5) and its corresponding 2'-deoxy analogue (6) exhibited high cytotoxicity instead of giving antiviral activities. (C) 2003 Elsevier Ltd. All rights reserved.

Keywords: ANALOGS; ANALOGS; thymine nucleosides; tetrahydrofuran

ISSN: 0960-894X

URI: https://pubs.kist.re.kr/handle/201004/138140

DOI: 10.1016/S0960-894X(03)00730-3

Appears in Collections:: KIST Article > 2003

Files in This Item:

Export: RIS (EndNote); XLS (Excel); XML

Show Full Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE