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dc.contributor.authorLee, JS-
dc.contributor.authorKim, HJ-
dc.contributor.authorLee, YS-
dc.date.accessioned2024-01-21T08:12:02Z-
dc.date.available2024-01-21T08:12:02Z-
dc.date.created2022-01-11-
dc.date.issued2003-09-
dc.identifier.issn0032-0943-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/138248-
dc.description.abstractA new flavonoid glucuronide, apigenin 7-O-beta-D-(4'-caffeoyl)glucuronide (1), and the known compound, apigenin 7-O-beta-D-glucuronide, were isolated from the flowers of Chrysanthemum morifolium, along with five known flavonoids. The structure of 1 was elucidated by the aid of spectroscopic analyses. Among isolated compounds, apigenin 7-O-beta-D-(4"-caffeoyl)glucuronide showed strong HIV-1 integrase inhibitory activity (IC50 = 7.2 +/- 3.4 mug/ml) and anti-HIV activity in a cell culture assay (EC50 = 41.86 +/- 1.43 mug/ml) using H-IIIB infected MT-4 cells.-
dc.languageEnglish-
dc.publisherGEORG THIEME VERLAG KG-
dc.subjectIMMUNODEFICIENCY-VIRUS TYPE-1-
dc.subjectC-13 NMR-
dc.subjectINTEGRASE-
dc.subjectGLYCOSIDES-
dc.subjectDERIVATIVES-
dc.subjectINHIBITORS-
dc.subjectMORIFOLIUM-
dc.subjectFLOWERS-
dc.titleA new anti-HIV flavonoid from glucoronide from Chrysanthemum marifolium-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationPLANTA MEDICA, v.69, no.9, pp.859 - 861-
dc.citation.titlePLANTA MEDICA-
dc.citation.volume69-
dc.citation.number9-
dc.citation.startPage859-
dc.citation.endPage861-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000186249500016-
dc.identifier.scopusid2-s2.0-0242288801-
dc.relation.journalWebOfScienceCategoryPlant Sciences-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryIntegrative & Complementary Medicine-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPlant Sciences-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaIntegrative & Complementary Medicine-
dc.type.docTypeArticle-
dc.subject.keywordPlusIMMUNODEFICIENCY-VIRUS TYPE-1-
dc.subject.keywordPlusC-13 NMR-
dc.subject.keywordPlusINTEGRASE-
dc.subject.keywordPlusGLYCOSIDES-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusINHIBITORS-
dc.subject.keywordPlusMORIFOLIUM-
dc.subject.keywordPlusFLOWERS-
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KIST Article > 2003
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