A new anti-HIV flavonoid from glucoronide from Chrysanthemum marifolium

Abstract

A new flavonoid glucuronide, apigenin 7-O-beta-D-(4'-caffeoyl)glucuronide (1), and the known compound, apigenin 7-O-beta-D-glucuronide, were isolated from the flowers of Chrysanthemum morifolium, along with five known flavonoids. The structure of 1 was elucidated by the aid of spectroscopic analyses. Among isolated compounds, apigenin 7-O-beta-D-(4"-caffeoyl)glucuronide showed strong HIV-1 integrase inhibitory activity (IC50 = 7.2 +/- 3.4 mug/ml) and anti-HIV activity in a cell culture assay (EC50 = 41.86 +/- 1.43 mug/ml) using H-IIIB infected MT-4 cells.