DSpace at KIST: Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor

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DSpace at KISTKIST Article 2002

Stereoselective synthesis of a novel apio analogue of neplanocin A as potential S-adenosylhomocysteine hydrolase inhibitor

Authors: Moon, HR; Kim, HO; Lee, KM; Chun, MW; Kim, JH; Jeong, LS

Issue Date: 2002-10-03

Publisher: AMER CHEMICAL SOC

Citation: ORGANIC LETTERS, v.4, no.20, pp.3501 - 3503

Abstract: [GRAPHICS] A total synthesis of apio-neplanocin A, which combines properties of apio nucleoside and neplanocin A and is a potential inhibitor of S-adenosylhomocysteine hydrolase, was accomplished starting from D-ribose via stereoselective hydroxymethylation and RCM reaction.

Keywords: CARBOCYCLIC ADENOSINE-ANALOGS; 2' -DEOXY-3' -THIACYTIDINE BCH-189; ANTIVIRAL ACTIVITY; L929 CELLS; MECHANISM; SPECTRUM; INVITRO; TARGET; AGENTS; CARBOCYCLIC ADENOSINE-ANALOGS; 2' -DEOXY-3' -THIACYTIDINE BCH-189; ANTIVIRAL ACTIVITY; L929 CELLS; MECHANISM; SPECTRUM; INVITRO; TARGET; AGENTS; synthesis

ISSN: 1523-7060

URI: https://pubs.kist.re.kr/handle/201004/139137

DOI: 10.1021/ol026624m

Appears in Collections:: KIST Article > 2002

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