Synthesis and antibacterial activity of 1 beta-methyl-2-(5-substituted thiazolo pyrrolidin-3-ylthio)carbapenem derivatives

Authors
Oh, CHCho, HWBaek, DCho, JH
Issue Date
2002-09
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.37, no.9, pp.743 - 754
Abstract
The synthesis of a new series of 1beta-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive including, MRSA and Gram-negative bacteria were tested and the effect of substituent on the thiazole ring was investigated. A particular compound (28c) having 4-amide substituted thiazole moiety showed the most potent antibacterial activity. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.
Keywords
CARBAPENEM; CARBAPENEM; 1 beta-methylcarbapenem; antibacterial activity; substituent effect
ISSN
0223-5234
URI
https://pubs.kist.re.kr/handle/201004/139249
DOI
10.1016/S0223-5234(02)01397-1
Appears in Collections:
KIST Article > 2002
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