Synthesis and antibacterial activity of 1 beta-methyl-2-(5-substituted thiazolo pyrrolidin-3-ylthio)carbapenem derivatives
- Authors
- Oh, CH; Cho, HW; Baek, D; Cho, JH
- Issue Date
- 2002-09
- Publisher
- ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
- Citation
- EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.37, no.9, pp.743 - 754
- Abstract
- The synthesis of a new series of 1beta-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive including, MRSA and Gram-negative bacteria were tested and the effect of substituent on the thiazole ring was investigated. A particular compound (28c) having 4-amide substituted thiazole moiety showed the most potent antibacterial activity. (C) 2002 Published by Editions scientifiques et medicales Elsevier SAS.
- Keywords
- CARBAPENEM; CARBAPENEM; 1 beta-methylcarbapenem; antibacterial activity; substituent effect
- ISSN
- 0223-5234
- URI
- https://pubs.kist.re.kr/handle/201004/139249
- DOI
- 10.1016/S0223-5234(02)01397-1
- Appears in Collections:
- KIST Article > 2002
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