Inhibition of angiogenesis by propolis

Authors
Song, YSPark, EHJung, KJJin, CB
Issue Date
2002-08
Publisher
PHARMACEUTICAL SOCIETY KOREA
Citation
ARCHIVES OF PHARMACAL RESEARCH, v.25, no.4, pp.500 - 504
Abstract
Propolis, obtained from honeybee hives, has been used in Oriental folk medicine as an anti-inflammatory, anti-carcinogenic, and immunomodulatory agent. There is considerable evidence suggesting that angiogenesis and chronic inflammation are codependent. Blockage of angiogenesis results in an anti-inflammatory effect. Ethanol (EEP) and ether extracts of propolis (REP), and caffeic acid phenethyl ester (CAPE), an active component of propolis, were examined for their anti-angiogenic activities using the chick embryo chorioallantoic membrane (CAM), and the calf pulmonary arterial endothelial (CPAE) cell proliferation, assays. The presence of EEP REP and CAPE inhibited angiogenesis in the CAM assay and the proliferation of CPAE cells. The results suggest that anti-angiogenic activities of EEP, REP and CAPE are also responsible for their anti-inflammatory effect.
Keywords
ACID PHENETHYL ESTER; RHEUMATOID-ARTHRITIS; ANTIBACTERIAL; CELLS; SYNOVIUM; EXTRACT; POTENT; ACID PHENETHYL ESTER; RHEUMATOID-ARTHRITIS; ANTIBACTERIAL; CELLS; SYNOVIUM; EXTRACT; POTENT; propolis; caffeic acid phenethyl ester; angiogenesis; chorioallantoic membrane; calf pulmonary arterial endothelial cells
ISSN
0253-6269
URI
https://pubs.kist.re.kr/handle/201004/139355
DOI
10.1007/BF02976609
Appears in Collections:
KIST Article > 2002
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