DSpace at KISTKIST Article2002

Full metadata record

DC Field Value Language
dc.contributor.authorCha, MY-
dc.contributor.authorChoi, BC-
dc.contributor.authorKang, KH-
dc.contributor.authorPae, AN-
dc.contributor.authorChoi, KI-
dc.contributor.authorCho, YS-
dc.contributor.authorKoh, HY-
dc.contributor.authorLee, HY-
dc.contributor.authorJung, D-
dc.contributor.authorKong, JY-
dc.date.accessioned2024-01-21T10:37:42Z-
dc.date.available2024-01-21T10:37:42Z-
dc.date.created2021-09-01-
dc.date.issued2002-05-20-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/139519-
dc.description.abstractA piperazinylbutylisoxazole libary was designed, synthesized and screened for the binding affinities to dopamine D-2, D-3, and D-4 receptors. Several ligands were identified to possess high binding affinity and selectivity for the D-3 and D-4 receptors over the D-2 receptor. Compounds 6s and 6t showed K-i values of 2.6 nM and 3.9 nM for the D-3 receptor with 46- and 50-fold selectivity over the D-3 receptor, respectively. (C) 2002 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectMOLECULAR-CLONING-
dc.subjectHIGH-AFFINITY-
dc.subjectD-3 RECEPTOR-
dc.subjectANTAGONIST-
dc.subjectGENE-
dc.subjectHALOPERIDOL-
dc.subjectEFFICACY-
dc.subjectAGONIST-
dc.subjectCYCLASE-
dc.subjectPOTENT-
dc.titleDesign and synthesis of a piperazinylalkylisoxazole library for subtype selective dopamine receptor ligands-
dc.typeArticle-
dc.identifier.doi10.1016/S0960-894X(02)00179-8-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.12, no.10, pp.1327 - 1330-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume12-
dc.citation.number10-
dc.citation.startPage1327-
dc.citation.endPage1330-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000175648800001-
dc.identifier.scopusid2-s2.0-18344391187-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusMOLECULAR-CLONING-
dc.subject.keywordPlusHIGH-AFFINITY-
dc.subject.keywordPlusD-3 RECEPTOR-
dc.subject.keywordPlusANTAGONIST-
dc.subject.keywordPlusGENE-
dc.subject.keywordPlusHALOPERIDOL-
dc.subject.keywordPlusEFFICACY-
dc.subject.keywordPlusAGONIST-
dc.subject.keywordPlusCYCLASE-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordAuthorpiperazinyalkylisoxazole-
Appears in Collections:
KIST Article > 2002
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Simple Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE