Synthesis and antibacterial activity of 1 beta-methyl-2-(5-substituted thiazolidinopyrrolidin-3-ylthio)carbapenems and related compounds

Abstract

The synthesis of a new series of 1beta-methylcarbapenems containing the substituted thiazolidinopyrrolidine moiety is described. Their in vitro antibacterial activities against both Gram-positive and Gram-negative bacteria were tested and the effect of substituent on the thiazolidine ring was investigated. A particular compound (18 c) having a 2-amide substituted thiazolidine moiety showed the most potent antibacterial activity.