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dc.contributor.authorNam, G-
dc.contributor.authorYoon, CM-
dc.contributor.authorKim, E-
dc.contributor.authorRhee, CK-
dc.contributor.authorKim, JH-
dc.contributor.authorShin, JH-
dc.contributor.authorKim, SH-
dc.date.accessioned2024-01-21T12:38:03Z-
dc.date.available2024-01-21T12:38:03Z-
dc.date.created2021-09-05-
dc.date.issued2001-03-12-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/140617-
dc.description.abstractThe syntheses and in vitro evaluation of a new series of pyrido[2,3-d]pyrimidine-2,4-diones bearing substituents at C-3 and/or C-4 positions on the pyridine ring are described. Some of these compounds, especially 51 and 6f, were found to be potent phosphodiesterase 4 (PDE 4) inhibitors exhibiting improved ratio of PDE 4 inhibitory activity:rolipram binding assay (RBA). (C) 2001 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectPOTENT-
dc.subjectPHOSPHODIESTERASE-4-
dc.titleSyntheses and evaluation of pyrido[2,3-d]pyrimidine-2,4-diones as PDE 4 inhibitors-
dc.typeArticle-
dc.identifier.doi10.1016/S0960-894X(00)00681-8-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.11, no.5, pp.611 - 614-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume11-
dc.citation.number5-
dc.citation.startPage611-
dc.citation.endPage614-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000167375700001-
dc.identifier.scopusid2-s2.0-0035848414-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusPOTENT-
dc.subject.keywordPlusPHOSPHODIESTERASE-4-
dc.subject.keywordAuthorPDE 4 inhibitors-
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KIST Article > 2001
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