Synthesis of novel D- and L-3 '-deoxy-3 '-C-hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor
- Authors
- Chun, MW; Kim, MJ; Jo, UH; Kim, JH; Kim, HD; Jeong, LS
- Issue Date
- 2001-03
- Publisher
- MARCEL DEKKER INC
- Citation
- NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.20, no.4-7, pp.703 - 706
- Abstract
- D- and L-3'-Deoxy-3'-C-hydroxymethyl thymidine substituted with exocyclic methylene at 2'-position were synthesized, starting from D- and L-xylose as potential ribonucleotide reductase inhibitor, respectively, but they were found to be inactive against several tumor cell lines.
- Keywords
- synthesis
- ISSN
- 1525-7770
- URI
- https://pubs.kist.re.kr/handle/201004/140695
- DOI
- 10.1081/NCN-100002355
- Appears in Collections:
- KIST Article > 2001
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