Synthesis of novel D- and L-3 '-deoxy-3 '-C-hydroxymethyl nucleoside with exocyclic methylene as potential ribonucleotide reductase inhibitor

Authors
Chun, MWKim, MJJo, UHKim, JHKim, HDJeong, LS
Issue Date
2001-03
Publisher
MARCEL DEKKER INC
Citation
NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.20, no.4-7, pp.703 - 706
Abstract
D- and L-3'-Deoxy-3'-C-hydroxymethyl thymidine substituted with exocyclic methylene at 2'-position were synthesized, starting from D- and L-xylose as potential ribonucleotide reductase inhibitor, respectively, but they were found to be inactive against several tumor cell lines.
Keywords
synthesis
ISSN
1525-7770
URI
https://pubs.kist.re.kr/handle/201004/140695
DOI
10.1081/NCN-100002355
Appears in Collections:
KIST Article > 2001
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