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dc.contributor.authorKim, NY-
dc.contributor.authorKang, TH-
dc.contributor.authorPae, HO-
dc.contributor.authorChoi, BM-
dc.contributor.authorChung, HT-
dc.contributor.authorMyung, SW-
dc.contributor.authorSong, YS-
dc.contributor.authorSohn, DH-
dc.contributor.authorKim, YC-
dc.date.accessioned2024-01-21T15:03:23Z-
dc.date.available2024-01-21T15:03:23Z-
dc.date.created2021-09-04-
dc.date.issued1999-10-
dc.identifier.issn0918-6158-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/141900-
dc.description.abstractBioassay-guided fractionation of an aqueous extract of Alismatis Rhizoma has furnished two inducible nitric oxide synthase (iNOS) inhibitory compounds, alismol (1) and alisol B monoacetate (2), together with an inactive triterpene, alisol C monoacetate (3). Compounds 1 and 2 inhibited nitric oxide (NO) synthesis in a dose-dependent manner in murine macrophage-like RAW 264.7 cells stimulated with interferon-gamma (IFN-gamma) plus lipopolysaccharide (LPS), The inhibitory effects of 1 and 2 on NO synthesis were partly due to suppression of iNOS mRNA expression as determined by Northern blotting.-
dc.languageEnglish-
dc.publisherPHARMACEUTICAL SOC JAPAN-
dc.subjectMETHANOL EXTRACT-
dc.titleIn vitro inducible nitric oxide synthesis inhibitors from Alismatis Rhizoma-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOLOGICAL & PHARMACEUTICAL BULLETIN, v.22, no.10, pp.1147 - 1149-
dc.citation.titleBIOLOGICAL & PHARMACEUTICAL BULLETIN-
dc.citation.volume22-
dc.citation.number10-
dc.citation.startPage1147-
dc.citation.endPage1149-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000083152600029-
dc.identifier.scopusid2-s2.0-0032735228-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusMETHANOL EXTRACT-
dc.subject.keywordAuthorAlismatis Rhizoma-
dc.subject.keywordAuthorinducible nitric oxide synthase (iNOS)-
dc.subject.keywordAuthorinhibitor-
dc.subject.keywordAuthorRAW 264.7 cell-
dc.subject.keywordAuthoralismol-
dc.subject.keywordAuthoralisol B monoacetate-
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