Synthesis and in vitro activity of new oxazolidinone antibacterial agents having substituted isoxazoles

Abstract

Two series of oxazolidinone derivatives having substituted isoxazoles were synthesized and tested for antibacterial activities against several Gram-positive strains including the resistant strains of Staphylococcus and Enterococcus, such as MRSA, CRSA, MSSA and VRE. Some of them showed in vitro activities (MIC) comparable or superior to the reference compound vancomycin. (C) 1999 Elsevier Science Ltd. All rights reserved.