Synthesis and biological evaluation of novel 1 beta-methylcarbapenems having a new moiety at C-2

Abstract

The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems 1a-f, bearing a variety of 3 ",4 "-disubstituted pyrrolidinamides as substituents at C-2, are described. Of these carbapenems, diol 1a showed the most potent and well balanced antibacterial activity against Gram-positive and Gram-negative, 1a was also evaluated for pharmacokinetics and in vivo therapeutic efficacy in systemic infections. (C) 1999 Elsevier Science Ltd. All rights reserved.