Synthesis of (diamine)platinum(II) and (diamine)platinum(IV) complexes of isopropylidenmalonate ligand and their interaction with guanosine-5 '-monophosphate

Authors
Lee, EJJun, MJSohn, YS
Issue Date
1998-10-20
Publisher
KOREAN CHEMICAL SOC
Citation
BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.19, no.10, pp.1099 - 1105
Abstract
A series of (diamine)isopropylidenmalonatoplatinum(II) complexes and the oxidation products, (diamine)Pt (OOC)(2)C=C(CH3)(2)(X)(2), (diamine-ethylenediamine(en), 1,2-diaminopropan(dap), N-methylethylenediamine(men); X=OH, OCOCH3, OCOCF3), have been prepared, and their interaction with guanosine-5'-monophosphate (5'-GMP) have been examined by means of H-1 NMR spectroscopy. The present platinum(II) complexes have shown to interact with 5'-GMP through N7 coordination in two concecutive steps in a similar way as with cisplatin, but no interaction between the present platinum(IV) complexes and 5'-GMP was observed. However, in the presence of ascorbic acid, the platinum(IV) complexes have been found to interact with 5'-GMP with the reaction rate depending on their reduction rate.
Keywords
PLATINUM ANTICANCER DRUG; DNA; CIS-DIAMMINEDICHLOROPLATINUM(II); PLATINUM ANTICANCER DRUG; DNA; CIS-DIAMMINEDICHLOROPLATINUM(II); platinum complexes
ISSN
0253-2964
URI
https://pubs.kist.re.kr/handle/201004/142795
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KIST Article > Others
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