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dc.contributor.authorShin, KJ-
dc.contributor.authorYoo, KH-
dc.contributor.authorKim, DJ-
dc.contributor.authorPark, SW-
dc.contributor.authorKo, BS-
dc.contributor.authorLee, SJ-
dc.contributor.authorHuh, JD-
dc.contributor.authorPark, SY-
dc.date.accessioned2024-01-21T16:45:35Z-
dc.date.available2024-01-21T16:45:35Z-
dc.date.created2022-01-11-
dc.date.issued1998-07-07-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/142953-
dc.description.abstractThe synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R-2=NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety. (C) 1998 Elsevier Science Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectBETA-LACTAM ANTIBIOTICS-
dc.subjectCARBAPENEM ANTIBIOTICS-
dc.titleSynthesis and biological properties of new 1 beta-methylcarbapenems-
dc.typeArticle-
dc.identifier.doi10.1016/S0960-894X(98)00270-4-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.8, no.13, pp.1607 - 1612-
dc.citation.titleBIOORGANIC & MEDICINAL CHEMISTRY LETTERS-
dc.citation.volume8-
dc.citation.number13-
dc.citation.startPage1607-
dc.citation.endPage1612-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000074871700006-
dc.identifier.scopusid2-s2.0-0032493406-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusBETA-LACTAM ANTIBIOTICS-
dc.subject.keywordPlusCARBAPENEM ANTIBIOTICS-
dc.subject.keywordAuthorantibiotics-
dc.subject.keywordAuthorantibacterials-
dc.subject.keywordAuthorsubstituent effects-
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