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Synthesis and biological properties of new 1 beta-methylcarbapenems

Authors
Shin, KJ; Yoo, KH; Kim, DJ; Park, SW; Ko, BS; Lee, SJ; Huh, JD; Park, SY
Issue Date
1998-07-07
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, v.8, no.13, pp.1607 - 1612
Abstract
The synthesis and biological activity of the novel series of 1 beta-methylcarbapenems, 1 and 2 were described. Most compounds displayed high potent antibacterial activity. The best compound in this series, 2a (IH201; R-2=NH2) showed an excellent and a broad spectrum as well as high renal DHP-I stability. It also possessed good in vivo efficacy and high safety. (C) 1998 Elsevier Science Ltd. All rights reserved.
Keywords
BETA-LACTAM ANTIBIOTICS; CARBAPENEM ANTIBIOTICS; BETA-LACTAM ANTIBIOTICS; CARBAPENEM ANTIBIOTICS; antibiotics; antibacterials; substituent effects
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/142953
DOI
10.1016/S0960-894X(98)00270-4
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KIST Article > Others
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