Formation of pyrazinoisoquinoline ring system by the tandem amidoalkylation and N-acyliminium ion cyclization: An efficient synthesis of Praziquantel

Abstract

An efficient synthesis of pyrazinoisoquinoline derivatives including Praziquantel has been accomplished by the tandem amidoalkylaion and N-acyliminium ion cyclization of amido-acetals. (C) 1998 Elsevier Science Ltd. All rights reserved.