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dc.contributor.authorChoo, HYP-
dc.contributor.authorYoon, HR-
dc.contributor.authorPark, HS-
dc.contributor.authorKim, DH-
dc.contributor.authorPark, J-
dc.contributor.authorKim, J-
dc.date.accessioned2024-01-21T17:11:29Z-
dc.date.available2024-01-21T17:11:29Z-
dc.date.created2021-09-03-
dc.date.issued1998-04-
dc.identifier.issn0253-6269-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/143157-
dc.description.abstractThe epoxyalkanoyl derivatives were designed and synthesized as ACE inhibitors. Coupling of unsaturated carboxylic acids with amino acids and following epoxidation with dimethyldioxirane gave the epoxyalkanoyls with high yield. The inhibitory activity of synthesized compounds on angiotensin converting enzyme was IC50 values of 0.06 similar to 5.5 mu M.-
dc.languageEnglish-
dc.publisherPHARMACEUTICAL SOCIETY KOREA-
dc.subjectANGIOTENSIN-CONVERTING ENZYME-
dc.subjectANTIHYPERTENSIVE AGENTS-
dc.subjectDESIGN-
dc.subjectACIDS-
dc.titleEpoxyalkanoyls as novel ACE inhibitors-
dc.typeArticle-
dc.identifier.doi10.1007/BF02974023-
dc.description.journalClass1-
dc.identifier.bibliographicCitationARCHIVES OF PHARMACAL RESEARCH, v.21, no.2, pp.168 - 173-
dc.citation.titleARCHIVES OF PHARMACAL RESEARCH-
dc.citation.volume21-
dc.citation.number2-
dc.citation.startPage168-
dc.citation.endPage173-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000073103200012-
dc.identifier.scopusid2-s2.0-0032035441-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryPharmacology & Pharmacy-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.type.docTypeArticle-
dc.subject.keywordPlusANGIOTENSIN-CONVERTING ENZYME-
dc.subject.keywordPlusANTIHYPERTENSIVE AGENTS-
dc.subject.keywordPlusDESIGN-
dc.subject.keywordPlusACIDS-
dc.subject.keywordAuthorepoxides-
dc.subject.keywordAuthorangiotensin converting enzyme inhibitor-
dc.subject.keywordAuthorirreversible inhibition-
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