Synthesis and antibacterial activities of new carbapenems having a proline reverse amide moiety at the C-2 position

Abstract

The synthesis of new 1 beta-methylcarbapenems (1a-1) having a proline reverse amide moiety at the C-2 position and their in vitro antibacterial activities are described. The compounds were evaluated by the Mueller-Hinton agar dilution method and compared with meropenem as control. Aliphatic amides (1a-h) are found to show greater antibacterial activity than aromatic amides (1i-1). Moreover, C-2 free amino compound (1m) reveals greater activity other amide compounds (1a-1).