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dc.contributor.authorKang, SB-
dc.contributor.authorPark, S-
dc.contributor.authorKim, YH-
dc.contributor.authorKim, Y-
dc.date.accessioned2024-01-21T18:41:23Z-
dc.date.available2024-01-21T18:41:23Z-
dc.date.created2021-09-05-
dc.date.issued1997-01-01-
dc.identifier.issn0385-5414-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/143986-
dc.description.abstractThe benzoxazinecarboxylic acid (8), a precursor of levofloxacin (1), was prepared from (S)-2-amino-1-propanol (2) in 4 steps in good overall yield. The synthesis is characterized by one pot construction of 8 from the useful benzoylacrylates (7) which are effectively prepared in three steps. The key intermediates (7) were obtained from 2-nitrobenzoyl derivative (6a) and 2-fluorobenzoyl derivative (6b) through acylation of the acrylates (5), respectively.-
dc.languageEnglish-
dc.publisherPERGAMON-ELSEVIER SCIENCE LTD-
dc.subjectOPTICALLY-ACTIVE OFLOXACIN-
dc.subjectANTIBACTERIAL ACTIVITIES-
dc.subjectDERIVATIVES-
dc.subjectAGENT-
dc.subjectACIDS-
dc.titleAn improved synthesis of levofloxacin-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationHETEROCYCLES, v.45, no.1, pp.137 - 145-
dc.citation.titleHETEROCYCLES-
dc.citation.volume45-
dc.citation.number1-
dc.citation.startPage137-
dc.citation.endPage145-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosidA1997WJ19100017-
dc.identifier.scopusid2-s2.0-0003174709-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusOPTICALLY-ACTIVE OFLOXACIN-
dc.subject.keywordPlusANTIBACTERIAL ACTIVITIES-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusAGENT-
dc.subject.keywordPlusACIDS-
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