Synthesis and biological activity of C-3 pyridinylethene-substituted cephalosporins

Abstract

A series of aminothiazolylcephalosporin derivatives (1a similar to 1c) having pyridinylethenyl group at C-3 position was prepared starting from phosphonium salt 3 and 2-, 3- or 4-pyridinecarboxaldehyde and the antibacterial activity of these compounds was investigated. Among them, 4-pyridinylethenyl derivative was more active than 2- and 3-pyridinylethenyl derivatives against Staphylococcus aureus and Escherichia coli.