CHROMATOGRAPHIC RESOLUTION OF RACEMIC ALPHA-HALOCARBOXYLIC ACIDS AND O-SUBSTITUTED ALPHA-HYDROXYCARBOXYLIC ACIDS VIA DIASTEREOMERIC N-ACYLOXAZOLIDINONES

Authors
SONG, CELEE, SGLEE, KCKIM, IOJEONG, JH
Issue Date
1993-11-19
Publisher
ELSEVIER SCIENCE BV
Citation
JOURNAL OF CHROMATOGRAPHY A, v.654, no.2, pp.303 - 308
Abstract
Diastereomeric pairs of N-acyloxazolidinones, derived from (4R,5S)-4-methyl-5-phenyl-2-oxazolidinon (as a chiral derivatizing agent) and racemic alpha-halocarboxylic acids or O-substituted alpha-hydroxycarboxylic acids, were separated chromatographically on a large preparative scale and showed appreciable degrees of NMR-shift difference. The origins of the chromatographic separability of these diastereomers are discussed.
Keywords
ASYMMETRIC HALOGENATION; GENERAL-APPROACH; AMINO-ACIDS; ESTERS; HYDROLYSIS; ALKYLATION; ALCOHOLS; ASYMMETRIC HALOGENATION; GENERAL-APPROACH; AMINO-ACIDS; ESTERS; HYDROLYSIS; ALKYLATION; ALCOHOLS
ISSN
0021-9673
URI
https://pubs.kist.re.kr/handle/201004/145950
DOI
10.1016/0021-9673(93)83374-2
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KIST Article > Others
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