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dc.contributor.authorKANG, HY-
dc.contributor.authorPAE, AN-
dc.contributor.authorKOH, HY-
dc.contributor.authorCHANG, MH-
dc.date.accessioned2024-01-21T23:46:56Z-
dc.date.available2024-01-21T23:46:56Z-
dc.date.created2022-01-10-
dc.date.issued1991-02-20-
dc.identifier.issn0253-2964-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/146835-
dc.description.abstractA series of compounds, N-(2-substituted-1-carboxy)vinylazetidinones were successfully synthesized in order to test the hypothesis that biological activities of beta-lactam antibiotics could be attributed to the smooth flow of electrons after a nucleophilic attack at the carbonyl carbon in the beta-lactam ring. After introduction of aminothiazolylacetamido group at 3-position of the azetidinones, their biological activities were evaluated. Their low activities led to the conclusion that the smooth electron flow in beta-lactams in not the sufficient source for the biological activities.-
dc.languageEnglish-
dc.publisherKOREAN CHEMICAL SOC-
dc.subjectLACTIVICIN-
dc.subjectPENEMS-
dc.titleSYNTHESIS AND BIOLOGICAL EVALUATIONS OF N-(2-SUBSTITUTED-1-CARBOXYL) VINYLAZETIDINONES - A STUDY ON THE ESSENTIAL STRUCTURAL ELEMENT FOR BIOLOGICAL-ACTIVITIES OF BETA-LACTAM ANTIBIOTICS-
dc.typeArticle-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.12, no.1, pp.75 - 79-
dc.citation.titleBULLETIN OF THE KOREAN CHEMICAL SOCIETY-
dc.citation.volume12-
dc.citation.number1-
dc.citation.startPage75-
dc.citation.endPage79-
dc.description.journalRegisteredClassscie-
dc.identifier.wosidA1991FA54600021-
dc.relation.journalWebOfScienceCategoryChemistry, Multidisciplinary-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusLACTIVICIN-
dc.subject.keywordPlusPENEMS-
dc.subject.keywordAuthorazetidinones-
dc.subject.keywordAuthorbiological activities-
dc.subject.keywordAuthorβ -lactam antibiotics-
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