Reactions of Podocarpic Acid Derivatives with Thallium(III) Nitrate

Abstract

The reaction of methyl 0-methyl-7-ketopodocarpate (3) with thallium(III) nitrate in acetic acid was performed in attempt to synthesize compound 4, an intermediate in the total synthesis of the plant growth hormone gibberellic acid. The reaction unexpectedly resulted in new methodology for the one-step formation of methyl O-methyl-A