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Synthesis and biological evaluation of chalcone analogues as protective agents against cisplatin-induced cytotoxicity in kidney cells

Authors
Lee, Dahae; Kim, Ki Hyun; Moon, Sung Won; Lee, Heesu; Kang, Ki Sung; Lee, Jae Wook
Issue Date
2015-05-01
Publisher
Pergamon Press Ltd.
Citation
Bioorganic & Medicinal Chemistry Letters, v.25, no.9, pp.1929 - 1932
Abstract
Chalcone analogues were prepared and evaluated for any renoprotective effects on cisplatin-treated cultured kidney cells (LLC-PK1); two chalcone analogues exhibited a potent renoprotective effect. In an additional study, we demonstrated that the blocking of MAPKs-p53-caspase-3 signaling cascade plays an important role in mediating the protective effect of these compounds against oxidative cytotoxicity in cultured LLC-PK1 cells. (C) 2015 Published by Elsevier Ltd.
Keywords
INDUCED APOPTOSIS; ANTICANCER; INJURY; INVOLVEMENT; DERIVATIVES; PATHWAYS; GINSENG; DAMAGE; ALPHA; INDUCED APOPTOSIS; ANTICANCER; INJURY; INVOLVEMENT; DERIVATIVES; PATHWAYS; GINSENG; DAMAGE; ALPHA; Chalcone; Cisplatin-induced nephrotoxicity; Renoprotection; MAPKs-p53-caspase-3
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/125462
DOI
10.1016/j.bmcl.2015.03.026
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KIST Article > 2015
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