DSpace at KIST: Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [C-11]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)

Synthesis and In vivo Evaluation of 5-Methoxy-2-(phenylethynyl)quinoline (MPEQ) and [C-11]MPEQ Targeting Metabotropic Glutamate Receptor 5 (mGluR5)

Authors: Kim, Ji Young; Son, Myung-Hee; Choi, Kihang; Baek, Du-Jong; Ko, Min Kyung; Lim, Eun Jeong; Pae, Ae Nim; Keum, Gyochang; Lee, Jae Kyun; Cho, Yong Seo; Choo, Hyunah; Lee, Youn Woo; Moon, Byung Seok; Lee, Byung Cheol; Lee, Ho-Young; Min, Sun-Joon

Citation: BULLETIN OF THE KOREAN CHEMICAL SOCIETY, v.35, no.8, pp.2304 - 2310

Abstract: The synthesis and in vivo evaluation of 5-methoxy-2-(phenylethynyl)quinoline (MPEQ) 3 as a potential mGluR5 selective radioligand is described. We have identified MPEQ 3 exhibiting the analgesic effect in the neuropathic pain animal model. The effect of mGluR5 on neuronal activity in rat brain was evaluated through FDG/PET imaging in the presence of MPEQ 3. In addition, the PET study of [C-11]MPEQ 3 proved that accumulation of [C-11]MPEQ 3 in rat brain was correlated to the localization of the mGluR5.

Keywords: RAT MODEL; PAIN; LOCALIZATION; ANTAGONIST; ALLODYNIA; PET; RAT MODEL; PAIN; LOCALIZATION; ANTAGONIST; ALLODYNIA; PET; MPEQ; Metabotropic glutamate receptor 5 (mGluR5); in vivo; PET imaging; Neuropathic pain

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