A polyacetylene-rich extract from Gymnaster koraiensis strongly inhibits colitis-associated colon cancer in mice

Authors
Butler, Shannon M.Wallig, Matthew A.Nho, Chu WonPan, Cheol-HoLee, Eun-HaJung, Sang HoonJeffery, Elizabeth H.
Issue Date
2013-03
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
FOOD AND CHEMICAL TOXICOLOGY, v.53, pp.235 - 239
Abstract
Gymnaster koraiensis (GK) is a Korean herb used in folk medicine and recently found to positively impact liver health. Because GK contains polyacetylenes and because other polyacetylenes have been found to exhibit anti-inflammatory and anti-cancer activities, we hypothesized that the polyacetylene gymnasterkoreayne B (GKB), known to increase hepatic detoxification enzymes, may also exert anti-inflammatory and anti-cancer activities. We fed male C57BL/6 mice purified AIN93G diets containing no additions, GKB or the GKB-rich fraction of an ethanol extract (GE) from GK to determine if these diets would slow or prevent either inflammation or inflammation-enhanced colon cancer, using the dextran sulfate sodium/azoxymethane mouse model. The GKB (500 mu mol/kg diet daily) showed some anti-inflammatory activity, but GE, containing an equal dose of GKB, protected strongly against both inflammation and colon cancer, decreasing adenocarcinomas by 90%. These data support further research into GK as a promising potential anti-cancer agent. (C) 2012 Elsevier Ltd. All rights reserved.
Keywords
BIOACTIVITY; INDUCTION; BIOACTIVITY; INDUCTION; Azoxymethane; Colon cancer; Dextran sulfate sodium; Prevention; Inflammation; Polyacetylene
ISSN
0278-6915
URI
https://pubs.kist.re.kr/handle/201004/128293
DOI
10.1016/j.fct.2012.11.049
Appears in Collections:
KIST Article > 2013
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