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Multi-core vesicle nanoparticles for controlled delivery of protein drug

Authors
Yuk, Soon Hong; Oh, Keun Sang; Kim, Seung Ki; Lee, Jin Ho; Cho, Sun Hang; Kim, Kwangmeyung; Jeon, Hyesung; Kwon, Ick Chan
Issue Date
2012-03
Publisher
POLYMER SOC KOREA
Citation
MACROMOLECULAR RESEARCH, v.20, no.3, pp.309 - 312
Abstract
The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.
Keywords
GH-DEFICIENT PATIENTS; GROWTH-HORMONE GH; COPOLYMER; FUSION; ENCAPSULATION; MICROSPHERES; SPECTROSCOPY; STABILITY; BILAYER; SYSTEMS; GH-DEFICIENT PATIENTS; GROWTH-HORMONE GH; COPOLYMER; FUSION; ENCAPSULATION; MICROSPHERES; SPECTROSCOPY; STABILITY; BILAYER; SYSTEMS; human growth hormone; Pluronic/PEG composite NPs; multi-core vesicle NPs; peptide drug; sustained release
ISSN
1598-5032
URI
https://pubs.kist.re.kr/handle/201004/129469
DOI
10.1007/s13233-012-0053-y
Appears in Collections:
KIST Article > 2012
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