DSpace at KISTKIST Article2012

Multi-core vesicle nanoparticles for controlled delivery of protein drug

Authors
Yuk, Soon Hong; Oh, Keun Sang; Kim, Seung Ki; Lee, Jin Ho; Cho, Sun Hang; Kim, Kwangmeyung; Jeon, Hyesung; Kwon, Ick Chan
Issue Date
2012-03
Publisher
POLYMER SOC KOREA
Citation
MACROMOLECULAR RESEARCH, v.20, no.3, pp.309 - 312
Abstract
The Pluronic/poly(ethylene glycol) composite nanoparticles (NPs) composed of Pluronic F-68, liquid poly(ethylene glycol) (PEG; molecular weight, 400) and human growth hormone (hGH) were stabilized with the vesicle fusion. When hGH-loaded Pluronic/PEG composite NPs were mixed with vesicles in the aqueous medium, hGH-loaded Pluronic/PEG composite NPs were incorporated into vesicles to form multi-core vesicle NPs. The morphology and size distribution of multi-core vesicle NPs were observed using field emission scanning electron microscopy, cryo-transmission electron microscopy, and a particle size analyzer. When multi-core vesicle NPs were applied as a delivery system for the protein drug, a sustained release pattern of hGH was observed.
Keywords
GH-DEFICIENT PATIENTS; GROWTH-HORMONE GH; COPOLYMER; FUSION; ENCAPSULATION; MICROSPHERES; SPECTROSCOPY; STABILITY; BILAYER; SYSTEMS; GH-DEFICIENT PATIENTS; GROWTH-HORMONE GH; COPOLYMER; FUSION; ENCAPSULATION; MICROSPHERES; SPECTROSCOPY; STABILITY; BILAYER; SYSTEMS; human growth hormone; Pluronic/PEG composite NPs; multi-core vesicle NPs; peptide drug; sustained release
ISSN
1598-5032
URI
https://pubs.kist.re.kr/handle/201004/129469
DOI
10.1007/s13233-012-0053-y
Appears in Collections:
KIST Article > 2012
Files in This Item:
There are no files associated with this item.
Export
RIS (EndNote)
XLS (Excel)
XML
Show Full Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE