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dc.contributor.authorOh, Sangtae-
dc.contributor.authorPark, Byong-Gon-
dc.contributor.authorHam, Jungyeob-
dc.contributor.authorLee, Seokjoon-
dc.date.accessioned2024-01-20T19:01:21Z-
dc.date.available2024-01-20T19:01:21Z-
dc.date.created2021-09-04-
dc.date.issued2010-07-15-
dc.identifier.issn0960-894X-
dc.identifier.urihttps://pubs.kist.re.kr/handle/201004/131256-
dc.description.abstractWe have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.-
dc.languageEnglish-
dc.publisherPergamon Press Ltd.-
dc.subjectNATURAL-PRODUCTS-
dc.subjectALZHEIMERS-DISEASE-
dc.subjectDERIVATIVES-
dc.subjectANTITUMOR-
dc.subjectDRUGS-
dc.titleSynthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits-
dc.typeArticle-
dc.identifier.doi10.1016/j.bmcl.2010.05.044-
dc.description.journalClass1-
dc.identifier.bibliographicCitationBioorganic & Medicinal Chemistry Letters, v.20, no.14, pp.4206 - 4209-
dc.citation.titleBioorganic & Medicinal Chemistry Letters-
dc.citation.volume20-
dc.citation.number14-
dc.citation.startPage4206-
dc.citation.endPage4209-
dc.description.journalRegisteredClassscie-
dc.description.journalRegisteredClassscopus-
dc.identifier.wosid000279258800048-
dc.identifier.scopusid2-s2.0-77953870731-
dc.relation.journalWebOfScienceCategoryChemistry, Medicinal-
dc.relation.journalWebOfScienceCategoryChemistry, Organic-
dc.relation.journalResearchAreaPharmacology & Pharmacy-
dc.relation.journalResearchAreaChemistry-
dc.type.docTypeArticle-
dc.subject.keywordPlusNATURAL-PRODUCTS-
dc.subject.keywordPlusALZHEIMERS-DISEASE-
dc.subject.keywordPlusDERIVATIVES-
dc.subject.keywordPlusANTITUMOR-
dc.subject.keywordPlusDRUGS-
dc.subject.keywordAuthorFarnesylacetones-
dc.subject.keywordAuthorVasodilatation-
dc.subject.keywordAuthorMarine natural product-
dc.subject.keywordAuthorOrganic synthesis-
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