DSpace at KISTKIST Article2010

Synthesis of two marine farnesylacetones that dilate the basilar arteries of rabbits

Authors
Oh, Sangtae; Park, Byong-Gon; Ham, Jungyeob; Lee, Seokjoon
Issue Date
2010-07-15
Publisher
Pergamon Press Ltd.
Citation
Bioorganic & Medicinal Chemistry Letters, v.20, no.14, pp.4206 - 4209
Abstract
We have synthesized novel vasodilatation farnesylacetones 1 and 2, which are major active constituents of Sargassum siliquastrum collected from the coast of the East Sea in Korea, in 9 steps. A test of the vasodilatation effect of synthetic intermediates and their deprotected compounds on the basilar arteries of rabbits revealed that 14 and 14-1 have a similar dilation effect as their target marine natural products 1 and 2. Crown Copyright (C) 2010 Published by Elsevier Ltd. All rights reserved.
Keywords
NATURAL-PRODUCTS; ALZHEIMERS-DISEASE; DERIVATIVES; ANTITUMOR; DRUGS; NATURAL-PRODUCTS; ALZHEIMERS-DISEASE; DERIVATIVES; ANTITUMOR; DRUGS; Farnesylacetones; Vasodilatation; Marine natural product; Organic synthesis
ISSN
0960-894X
URI
https://pubs.kist.re.kr/handle/201004/131256
DOI
10.1016/j.bmcl.2010.05.044
Appears in Collections:
KIST Article > 2010
Export
RIS (EndNote)
XLS (Excel)
XML
Show Full Item Record

qrcode

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

BROWSE