DSpace at KIST: Production of chromopyrrolic acid by coexpression of inkOD in a heterologous host Streptomyces albus

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Production of chromopyrrolic acid by coexpression of inkOD in a heterologous host Streptomyces albus

Authors: Chae, Choong-Sik; Park, Jin-Soo; Chung, Soon-Chun; Kim, Tae-Im; Lee, So-Hyoung; Yoon, Kyung-Mi; Shin, Jongheon; Oh, Ki-Bong

Issue Date: 2009-03-15

Publisher: Pergamon Press Ltd.

Citation: Bioorganic & Medicinal Chemistry Letters, v.19, no.6, pp.1581 - 1583

Abstract: Two ink genes, inkO and inkD, responsible for the earliest steps of K252a biosynthetic pathway, from Nonomurea longicantena JCM 11136 were heterologously coexpressed in Streptomyces albus J1074. The resultant strain accumulated compound that was purified by HPLC and studied by NMR. Coexpression of inkOD yielded chromopyrrolic acid, the key intermediate in an indolocarbazole biosynthesis. (C) 2009 Elsevier Ltd. All rights reserved.

Keywords: BIOSYNTHETIC GENE-CLUSTER; LECHEVALIERIA-AEROCOLONIGENES ATCC-39243; INDOLOCARBAZOLE COMPOUNDS; ANTICANCER AGENTS; REBECCAMYCIN; GENERATION; DERIVATIVES; BIOSYNTHETIC GENE-CLUSTER; LECHEVALIERIA-AEROCOLONIGENES ATCC-39243; INDOLOCARBAZOLE COMPOUNDS; ANTICANCER AGENTS; REBECCAMYCIN; GENERATION; DERIVATIVES; K252a; Heterologous expression; Chromopyrrolic acid; Streptomyces albus J1074

ISSN: 0960-894X

URI: https://pubs.kist.re.kr/handle/201004/132651

DOI: 10.1016/j.bmcl.2009.02.026

Appears in Collections:: KIST Article > 2009

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