Synthesis of sulfonyl curcumin mimics exerting a vasodilatation effect on the basilar artery of rabbits

Abstract

In order to discover novel small vasodilatory molecules for potential use in the treatment of vascular disease, we tested the vasodilatation effect of two types of synthetic curcumin mimics, amide type (3) and sulfonyl amide type (4), upon the basilar artery of rabbits. In general, the sulfonyl amide type mimic (4) is more potent than the amide type (3). Curcumin (1) and compounds 12 and 20 effectively dilated the basilar artery of white rabbits. Crown Copyright (C) 2009 Published by Elsevier Ltd. All rights reserved.