Novel synthesis of 4 ' C-aryl-branched acyclic nucleoside using [3,3]-sigmatropic rearrangement

Abstract

A very efficient synthetic route for preparing a novel 4'-C-aryl branched-1',2'-seco-2',3'-dideoxy-2',3'-didehydro-nucleoside is described. Mesylate 7 was successfully synthesized via a Horner-Wadsworth-Emmons reaction and a [3,3]-sigmatropic rearrangement, with which an adenine base was coupled by nucleophilic substitution conditions (K2CO3, 18-Crown-6, DMF) to give the target nucleoside 9.