Synthesis and antibacterial activities of 4-pyrrolidinylthio carbapenems: Containing heteroaromatics as a side chain
- Authors
- Cho, HW; Oh, CH; Lee, JS; Lee, SC; Choi, JH; Cho, JH
- Issue Date
- 2003-11
- Publisher
- WILEY-V C H VERLAG GMBH
- Citation
- ARCHIV DER PHARMAZIE, v.336, no.11, pp.495 - 503
- Abstract
- The synthesis of a new series of 2-alkyl-4-pyrrolidinylthio-b-methylcarbapenems containing the substituted heteroaromatic moieties is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested. The effect of substituents on the nitrogen atoms at heteroaromatic rings was investigated. Particular compounds (14b, 14c) containing 3-methyl- and 3,5-dimethylpyrazolethio substituted moiety showed the most potent antibacterial activity.
- Keywords
- 1-BETA-METHYLCARBAPENEM; THIENAMYCIN; ANTIBIOTICS; FR21818; 1-BETA-METHYLCARBAPENEM; THIENAMYCIN; ANTIBIOTICS; FR21818; carbapenems; antibacterials; DHP-I stability
- ISSN
- 0365-6233
- URI
- https://pubs.kist.re.kr/handle/201004/138128
- DOI
- 10.1002/ardp.200300728
- Appears in Collections:
- KIST Article > 2003
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