A new anti-HIV flavonoid from glucoronide from Chrysanthemum marifolium

Authors
Lee, JSKim, HJLee, YS
Issue Date
2003-09
Publisher
GEORG THIEME VERLAG KG
Citation
PLANTA MEDICA, v.69, no.9, pp.859 - 861
Abstract
A new flavonoid glucuronide, apigenin 7-O-beta-D-(4'-caffeoyl)glucuronide (1), and the known compound, apigenin 7-O-beta-D-glucuronide, were isolated from the flowers of Chrysanthemum morifolium, along with five known flavonoids. The structure of 1 was elucidated by the aid of spectroscopic analyses. Among isolated compounds, apigenin 7-O-beta-D-(4"-caffeoyl)glucuronide showed strong HIV-1 integrase inhibitory activity (IC50 = 7.2 +/- 3.4 mug/ml) and anti-HIV activity in a cell culture assay (EC50 = 41.86 +/- 1.43 mug/ml) using H-IIIB infected MT-4 cells.
Keywords
IMMUNODEFICIENCY-VIRUS TYPE-1; C-13 NMR; INTEGRASE; GLYCOSIDES; DERIVATIVES; INHIBITORS; MORIFOLIUM; FLOWERS; IMMUNODEFICIENCY-VIRUS TYPE-1; C-13 NMR; INTEGRASE; GLYCOSIDES; DERIVATIVES; INHIBITORS; MORIFOLIUM; FLOWERS
ISSN
0032-0943
URI
https://pubs.kist.re.kr/handle/201004/138248
Appears in Collections:
KIST Article > 2003
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