Synthesis and antibacterial activity of 1 beta-methyl-2-[5-(N-substituted-2-hydroxy iminoethyl)pyrrolidin-3-ylthio]carbapenem derivatives

Authors
Oh, CHLee, SCCho, JH
Issue Date
2003-07
Publisher
ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, v.38, no.7-8, pp.751 - 758
Abstract
The synthesis of a new series of 1-methylcarbapenems having the substituted thiazolopyrrolidine moiety is described. Their in vitro antibacterial activities against both gram-positive and gram-negative bacteria were tested and the effect of substituent on the pyrrolidine ring was investigated. In particular, compounds 12b and 12k showed the most potent antibacterial activity. (C) 2003 Editions scientifiques et medicales Elsevier SAS. All rights reserved.
Keywords
CARBAPENEM; CARBAPENEM; 1 beta-methylcarbapenem; beta-lactam antibiotics
ISSN
0223-5234
URI
https://pubs.kist.re.kr/handle/201004/138407
DOI
10.1016/S0223-5234(03)00116-8
Appears in Collections:
KIST Article > 2003
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