Synthesis and anti-HCMV activity of novel acyclic nucleosides
- Authors
- Lee, JY; Oh, CH; Ko, OH; Hong, JH
- Issue Date
- 2002-12
- Publisher
- TAYLOR & FRANCIS INC
- Citation
- NUCLEOSIDES NUCLEOTIDES & NUCLEIC ACIDS, v.21, no.10, pp.709 - 721
- Abstract
- A series of novel acyclic nucleosides 10, 11, 21, and 22 were synthesized efficiently starting from D-lactose. The condensation of the mesylate 5 and 16 with an adenine and cytosine base under standard nucleophilic substitution conditions (K2CO3, 18-Crown-6, DMF) afforded a series of acyclic novel nucleosides. Compound 21 displayed moderate anti-HCMV activity in the AD-169 cells (EC50 = 18.5 mug/mL) without exhibiting any cytotoxicity up to 100 muM.
- Keywords
- SIMPLEX VIRUS TYPE-1; ANTIVIRAL ACTIVITY; ANALOGS; SIMPLEX VIRUS TYPE-1; ANTIVIRAL ACTIVITY; ANALOGS; nucleoside
- ISSN
- 1525-7770
- URI
- https://pubs.kist.re.kr/handle/201004/139005
- DOI
- 10.1081/NCN-120015727
- Appears in Collections:
- KIST Article > 2002
- Files in This Item:
There are no files associated with this item.
- Export
- RIS (EndNote)
- XLS (Excel)
- XML
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.