DSpace at KISTKIST Article2001

Enzymatic kinetic resolution of ketorolac

Authors
Kim, YH; Cheong, CS; Lee, SH; Kim, KS
Issue Date
2001-07-30
Publisher
PERGAMON-ELSEVIER SCIENCE LTD
Citation
TETRAHEDRON-ASYMMETRY, v.12, no.13, pp.1865 - 1869
Abstract
Ketorolac was resolved into each enantiomer by interesterification using lipase B from Candida antarctica. The acid reacted with various alcohols and the ester and acid were resolved up to > 99% e.e. when reacted with octanol, which was the best result. To increase reactivity and enantioselectivity, the experimental conditions were adjusted by varying temperature, solvent, alcohols and reaction time. (C) 2001 Published by Elsevier Science Ltd.
Keywords
METABOLIC CHIRAL INVERSION; 2-ARYLPROPIONIC ACIDS; LIPASE; ENANTIOSELECTIVITY; ESTERIFICATION; CONSEQUENCES; METABOLIC CHIRAL INVERSION; 2-ARYLPROPIONIC ACIDS; LIPASE; ENANTIOSELECTIVITY; ESTERIFICATION; CONSEQUENCES; kinetic resolution
ISSN
0957-4166
URI
https://pubs.kist.re.kr/handle/201004/140304
DOI
10.1016/S0957-4166(01)00332-9
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KIST Article > 2001
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