Induction of diastereoselectivity in Fe(II) tris(amino acid-bipyridine) complexes

Abstract

A group of iron(II) tris-bipyridine complexes bearing L-amino acids (L-Lys, L-Phe, L-Ser, L-Val) was prepared to investigate the predetermination of chirality of metal complexes by the chiral amino acid subunits. Noncovalent interactions and solvent polarity seemed to be important factors in inducing diastereoselectivity of the metal complexes. These phenomena were explained by H-1 NMR and CD spectroscopic studies and molecular mechanics calculations.